Research progress on intestinal microecology regulating mechanism and biological activities of polysaccharides.
10.19540/j.cnki.cjcmm.20210623.701
- Author:
Ting TANG
1
;
Hua-Guo CHEN
1
;
Chao ZHAO
1
;
Xiao-Jian GONG
1
;
Qing-Fang DENG
1
;
Xin ZHOU
1
Author Information
1. Collaborative Innovation Center for Karst Mountain Ecological Environmental Protection and Resource Utilization,Guizhou Normal University, Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment Guiyang 550001, China.
- Publication Type:Review
- Keywords:
biological activity;
intestinal microecology;
mechanism of action;
polysaccharides
- MeSH:
Anti-Inflammatory Agents;
Ecosystem;
Gastrointestinal Microbiome;
Humans;
Intestines;
Polysaccharides/pharmacology*
- From:
China Journal of Chinese Materia Medica
2021;46(21):5585-5592
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal microecology is an important defense system in the human body. The intestinal flora is the core micro-ecosystem in the human intestine. It has a symbiotic relationship with the overall functions of the body. It has strong metabolic activity to maintain the normal functioning of the body and resist the invasion of various viral antigens in the body. Playing a protective function,the imbalanced intestinal microecology can cause various diseases. Polysaccharides can be extracted from a wide range of sources and have low toxicity and side effects. They have attracted wide attention because of their anti-tumor, anti-oxidant, anti-inflammatory and other biological activities. Studies have demonstrated that polysaccharides can regulate intestinal microecological disorders. According to the studies in recent years, this review summarizes that polysaccharides mainly modulate intestinal microecological disorders through regulating the composition of intestinal flora, improving the metabolism of the flora, and repairing the intestinal tract barrier. On the basis of these mechanisms of action, this paper elaborates the anti-tumor, immunomodulatory, and anti-inflammatory activities of polysaccharides. This paper can provide reference for the future research on the intestinal microecology-regulating mechanism and biological activities of polysaccharides.
