Research on Q-markers of Eupatorium lindleyanum based on analytic hierarchy process-entropy weight method and network pharmacology.
10.19540/j.cnki.cjcmm.20210813.201
- Author:
Lu HUANG
1
;
Ding-Qiao XU
1
;
Shi-Jun YUE
1
;
Yan-Yan CHEN
1
;
Rui-Jia FU
1
;
Zhe LU
1
;
Yu-Ping TANG
1
Author Information
1. Key Laboratory of Shaanxi A dministration of Traditional Chinese Medicine for Traditional Chinese Medicine Compatibility,Shaanxi University of Chinese Medicine Xi'an 712046, China.
- Publication Type:Journal Article
- Keywords:
Eupatorium lindleyanum;
analytic hierarchy process-entropy weight method;
network pharmacology;
quality marker(Q-marker)
- MeSH:
Analytic Hierarchy Process;
Drugs, Chinese Herbal;
Entropy;
Eupatorium;
Network Pharmacology;
Rutin
- From:
China Journal of Chinese Materia Medica
2021;46(21):5545-5554
- CountryChina
- Language:Chinese
-
Abstract:
The potential quality markers( Q-markers) of Eupatorium lindleyanum were studied with analytic hierarchy process(AHP)-entropy weight method(EWM) and network pharmacological method. Based on the concept of Q-markers of traditional Chinese medicine, AHP-EWM was employed to quantitatively identify the Q-markers of E. lindleyanum. AHP method was applied to the weight analysis of the validity, testability, and specificity of the first-level indexes, and EWM method was used to analyze the secondlevel indexes supported by literature and experimental data. At the same time, based on the theory and method of network pharmacology, the component-target-disease-efficacy network of E. lindleyanum was built, and the components most closely related to the efficacy of resolving phlegm and relieving cough and asthma were screened out. Through the integrated analysis of the results obtained with AHP-EWM and network pharmacological method, 13 compounds including rutin, quercetin, nepetin, cirsiliol, luteolin, hyperoside,isoquercitrin, kaempferol, caffeic acid, eupalinolide K, eupalinolide A, eupalinolide B, and eupalinolide C were comprehensively identified as the potential Q-markers of E. lindleyanum. The results provide a basis for the quality control of E. lindleyanum.
