Complanatoside A and complanatoside B in rats administered with raw and salt-processed Astragali Complanati Semen: a pharmacokinetics study.
10.19540/j.cnki.cjcmm.20210304.301
- Author:
Xian-Kuo YU
1
;
Hong-Wei WU
1
;
Han-Yan LUO
1
;
Xiao ZHANG
1
;
Ya-Qi LU
1
;
Li-Ying TANG
1
;
Zhu-Ju WANG
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
Astragali Complanati Semen;
complanatoside A;
complanatoside B;
pharmacokinetics;
processing
- MeSH:
Animals;
Astragalus Plant;
Chromatography, High Pressure Liquid;
Chromatography, Liquid;
Glycosides;
Rats;
Semen;
Tandem Mass Spectrometry
- From:
China Journal of Chinese Materia Medica
2021;46(22):5953-5957
- CountryChina
- Language:Chinese
-
Abstract:
An UPLC-MS/MS method was developed to simultaneously determine complanatoside A and complanatoside B in rat plasma with rutin as the internal standard and applied to examine the effect of salt-processing on pharmacokinetics of these two flavonoid glycosides. The pharmacokinetic parameters were estimated using DAS 3.2.6 and subjected to independent sample t-test with SPSS 23.0. No significant difference in T_(max) of complanatoside B was observed between the raw and processed groups; however, in the processed group, C_(max) and AUC_(0-12 h) of complanatoside B increased obviously(P<0.05), while MRT_(0-12 h) decreased from(3.34±0.44) h to(1.81±0.36) h(P<0.05). C_(max) [(14.72±11.13) μg·L~(-1)] and MRT_(0-24) [(3.93±0.26) h] of complanatoside A in the raw group were statistically different from those [(35.64±21.99) μg·L~(-1),(1.43±0.24) h] in the processed group(P<0.05). As a result, salt-processing can facilitate the in vivo adsorption and accelerate the excretion of complanatoside A and complanatoside B.
