Correlation of gut microbiota and ischemic stroke: a review.
10.19540/j.cnki.cjcmm.20210628.702
- Author:
Yu-Hao DAI
1
;
Li-Ming LIU
1
;
Chen LIU
1
;
Wen-Jie WU
2
;
Jian-Ying SHEN
1
;
Shao-Jing LI
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
2. Anhui University of Chinese Medicine Hefei 230012,China.
- Publication Type:Review
- Keywords:
16S rRNA;
gut microbiota;
ischemic stroke;
microbiota-gut-brain axis
- MeSH:
Brain;
Brain-Gut Axis;
Gastrointestinal Microbiome;
Humans;
Ischemic Stroke;
Stroke/genetics*
- From:
China Journal of Chinese Materia Medica
2021;46(22):5773-5780
- CountryChina
- Language:Chinese
-
Abstract:
With the widespread application of next-generation sequencing(NGS), especially 16 S rRNA and shotgun sequencing, researchers are no longer troubled with massive data on the gut microbiota, and the correlation between the gut microbiota and the brain(central nervous system) has been gradually revealed. Research on the microbiota-gut-brain axis(MGBA) based on the gut microbiota have provided insights into the exploration of the pathogenesis and risk factors of ischemic stroke(IS), a cerebrovascular disease with high disability and mortality rates, and also facilitate the selection of therapeutic targets of this class of drugs. This study reviewed the application of NGS in the study of gut microbiota and the research progress of MGBA in recent years and systematically collated the research papers on the correlation between IS and gut microbiota. Furthermore, from the bi-directional regulation of MGBA, this study also discussed the high-risk factors of IS under the dysregulation of gut microbiota and the pathophysiological changes of gut microbiota after the occurrence of IS and summarized the related targets to provide a reliable reference for the therapeutic research of IS from the gut microbiota.
