Non-alkaloid constituents of Hymenocallis littoralis.
10.19540/j.cnki.cjcmm.20210610.320
- Author:
Zhi-Wen DUAN
1
;
Jie ZHANG
1
;
Xiao-Juan CHEN
1
;
Xu PANG
2
;
Bai-Ping MA
1
Author Information
1. Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Science Beijing 100850, China.
2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Science Beijing 100850, China Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 300193, China.
- Publication Type:Journal Article
- Keywords:
Amarylliaceae;
Hymenocallis littoralis;
isolation;
non-alkaloid constituents;
structural identification
- MeSH:
Alkaloids;
Amaryllidaceae;
Chromones;
Liliaceae
- From:
China Journal of Chinese Materia Medica
2021;46(20):5304-5309
- CountryChina
- Language:Chinese
-
Abstract:
Perennial herb Hymenocallis littoralis(Amaryllidaceae) boasts anti-tumor, anti-virus, and anti-inflammatory activities. As the representative constituents, alkaloids have attracted much attention, whereas the non-alkaloid constituents have been rarely reported. Therefore, this study investigated the non-alkaloid constituents of H. littoralis and their contribution to the various pharmacological activities of the herb. Thirteen non-alkaloid compounds were isolated from the 95% ethanol extract of dried whole plant of H. littoralis after a series of chromatographic separation steps and spectral analysis, and they were identified as 5,7-dihydroxy-6,8-dimethoxy-2-hydroxymethyl-4H-chromoen-4-one(1), undulatoside A(2),(2S)-7,4'-dihydroxyflavane(3), naringenin(4), 4',7-hydroxy-8-methylflavanone(5), 8-methylnaringenin(6), 8-demethylfarrerol(7), 6-methyl-aromadendrin(8), 4',5,7-trihydroxy-8-methylflavanone(9), syzalterin(10), 6-methylapigenin(11), isoliquiritigenin(12), and undatuside C(13) based on the spectroscopic data analysis. Among them, compound 1 was a new chromone derivative, and compounds 2 and 4-13 were isolated form this plant for the first time.
