Enhancing effect and mechanism of muscone on transdermal penetration of traditional Chinese medicine ingredients with different log P value.
10.19540/j.cnki.cjcmm.20210129.303
- Author:
Xin-Yu ZHAO
1
;
Jing-Yan WANG
1
;
Li-Li DENG
1
;
Yu-Juan LIU
1
;
Zi-You GUO
1
;
Qing WU
1
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
- Publication Type:Journal Article
- Keywords:
ATR-FTIR;
muscone;
stratum corneum;
transdermal enhancing mechanism;
transdermal penetration
- MeSH:
Administration, Cutaneous;
Animals;
Cycloparaffins;
Medicine, Chinese Traditional;
Permeability;
Rats;
Rats, Sprague-Dawley;
Skin/metabolism*;
Skin Absorption
- From:
China Journal of Chinese Materia Medica
2021;46(20):5284-5290
- CountryChina
- Language:Chinese
-
Abstract:
This study aimed to investigate the enhancing effect of muscone on the transdermal penetration of traditional Chinese medicine ingredients and explore its possible mechanism of action. The Franz diffusion cells were employed to investigate the effect of muscone on the transdermal permeation of a series of model drugs with a wide range of log P values. The solubilities at saturation and the stratum corneum(SC)/vehicle partition coefficients of model drugs were measured to evaluate the effect of muscone on drug thermodynamic activities and partition of drugs into SC. Attenuated total reflectance-Fourier transform infrared spectroscopy(ATR-FTIR) was employed to explore the effect of muscone on the molecular structure of SC. The results showed that muscone significantly promoted the transdermal penetration of hydrophilic and lipophilic drugs, and the enhancement ratio(ER) increased with the decrease in the log P. Muscone could interact with the SC lipids to increase the disorder and fluidity of lipid bilayer packing, which improved skin permeability and promoted transdermal absorption of drugs. This study provides a scientific basis for the application of muscone in traditional Chinese medicine topical preparations.
