Effects of Buyang Huanwu Decoction on neurovascular units after cerebral ischemia: a review.
10.19540/j.cnki.cjcmm.20210610.706
- Author:
Xiao-Yu ZHENG
1
;
Ye-Hao ZHANG
2
;
Wen-Ting SONG
2
;
Hui CAO
2
;
Jian-Xun LIU
2
Author Information
1. Beijing Key Laboratory of Pharmacology of Chinese Materia Medica, Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China Beijing University of Chinese Medicine Beijing 100029, China.
2. Beijing Key Laboratory of Pharmacology of Chinese Materia Medica, Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
- Publication Type:Review
- Keywords:
Buyang Huanwu Decoction;
blood-brain barrier;
cerebral ischemia;
neurovascular unit
- MeSH:
Brain Ischemia/drug therapy*;
Cerebral Infarction;
Drugs, Chinese Herbal;
Humans;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2021;46(20):5226-5232
- CountryChina
- Language:Chinese
-
Abstract:
Buyang Huanwu Decoction, a representative prescription in traditional Chinese medicine(TCM) for tonifying Qi and activating blood, has been proved to be effective in preventing and treating acute cerebral infarction(ACI). It consists of Astragali Radix, Angelicae Sinensis Radix, Paeoniae Radix Rubra, Pheretima, Chuanxiong Rhizoma, Carthami Flos, and Persicae Semen, possessing multiple active ingredients. The neurovascular unit is a functionally and structurally interdependent multicellular complex composed of neurons-glial cells-blood vessels. It plays an important role in the pathological changes of cerebral ischemia and the permeability variation of the blood-brain barrier. In recent years, Buyang Huanwu Decoction has been found to protect the integrity of neurovascular units and improve the permeability of the blood-brain barrier, thereby alleviating stroke and other diseases caused by cerebral ischemia. This paper collated and summarized the protective effects of Buyang Huanwu Decoction on neurovascular units.