Research progress in pharmacology and toxicology of evodiamine.
10.19540/j.cnki.cjcmm.20210518.602
- Author:
Chun-Qi YANG
1
;
Wen-Yu LIAN
2
;
Yu-Guang WANG
3
;
Yue GAO
3
Author Information
1. Anhui Medical University Hefei 230032, China Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences Beijing 100850, China.
2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences Beijing 100850, China Guangdong Pharmaceutical University Guangzhou 510006, China.
3. Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences Beijing 100850, China.
- Publication Type:Journal Article
- Keywords:
TGF-β;
evodiamine;
pharmacology;
toxicology
- MeSH:
Evodia;
Hand Dermatoses;
Humans;
Plant Extracts;
Quinazolines/toxicity*;
Tinea
- From:
China Journal of Chinese Materia Medica
2021;46(20):5218-5225
- CountryChina
- Language:Chinese
-
Abstract:
Evodiamine, a bioactive indole alkaloid from Evodia rutaecarpa, E. rutaecarpa var. officinalis, or E. rutaecarpa var. bodinieri, has been extensively investigated due to its pharmacological activities in recent years. At present, evodiamine is proved to significantly suppress the proliferation of a variety of cancer cells and mediate cell processes such as cell cycle arrest and cell migration. In addition, evodiamine displays significant pharmacological activities against cardiovascular diseases(hyperlipidemia, etc.), and tinea manus and pedis. Recently, evodiamine has been found to have potential toxic effects, such as hepatotoxicity, nephrotoxicity, and cardiotoxicity. However, the pharmacological and toxicological mechanism of evodiamine is not clear, and its toxicity in vitro and in vivo has been rarely reported. Therefore, this study reviewed the pharmacological and toxicological articles of evodiamine in recent years, aiming at providing new ideas and references for future research.
