Chemical constituents and pharmacological action of bile acids from animal:a review.
10.19540/j.cnki.cjcmm.20210630.201
- Author:
Xing-Ling CHEN
1
;
Shu-Lan SU
1
;
Rui LIU
1
;
Da-Wei QIAN
1
;
Li-Ling CHEN
2
;
Li-Ping QIU
2
;
Jin-Ao DUAN
1
Author Information
1. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae, Nanjing University of Chinese Medicine Nanjing 210023, China.
2. The FJ (Fujian) into Allah Pharmaceutical Co. Hui'an 362142, China.
- Publication Type:Review
- Keywords:
animal bile;
bile acid;
chemical constituent;
hepatointestinal metabolism;
pharmacological effect
- MeSH:
Animals;
Bile Acids and Salts;
Cattle;
Chenodeoxycholic Acid;
Cholic Acids;
Deoxycholic Acid;
Female;
Swine;
Ursodeoxycholic Acid
- From:
China Journal of Chinese Materia Medica
2021;46(19):4898-4906
- CountryChina
- Language:Chinese
-
Abstract:
Bile of animal(mainly chicken, pig, snake, cow, and bear) has long been used as medicine. As the major active components of bile, bile acids mainly include cholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid, and taurochenodeoxycholic acid. They interact with intestinal microorganisms in enterohepatic circulation, thereby playing an important part in nutrient absorption and allocation, metabolism regulation, and dynamic balance. Bile acids have pharmacological effects such as protecting liver, kidney, heart, brain, and nerves, promoting bile secretion, dissolving gallstones, anti-cancer, relieving cough and dyspnea, dispelling phlegm, treating eye diseases, and regulating intestinal function and blood glucose, which are widely used in clinical practice. This study summarized and analyzed the research on the chemical constituents and pharmacological effects of bile acids from medicinal animals, in a bid to provide scientific basis and reference for the further development and utilization of bile acids.
