Polycyclic polyprenylated acylphloroglucinols from Hypericum species and their biological activities.
10.19540/j.cnki.cjcmm.20210603.601
- Author:
Ping SONG
1
;
Ji HAO
2
;
Yan WANG
1
;
Xin-Zhou YANG
2
Author Information
1. School of Chemistry and Chemical Engineering, Qinghai University for Nationalities Xining 810007, China.
2. School of Pharmaceutical Sciences, South-Central University for Nationalities Wuhan 430074, China.
- Publication Type:Journal Article
- Keywords:
Hypericum;
biological activity;
polycyclic polyprenylated acylphloroglucinol;
research progress
- MeSH:
Flavonoids;
Hypericum;
Molecular Structure;
Phloroglucinol/pharmacology*;
Xanthones
- From:
China Journal of Chinese Materia Medica
2021;46(19):4881-4890
- CountryChina
- Language:Chinese
-
Abstract:
Hypericum species are distributed widely in China, especially in the southwest. This genus is rich in species types in China, including 55 species and 8 subspecies. The main chemical constituents of Hypericum species are flavonoids, xanthones and polycyclic polyprenylated acylphloroglucinols(PPAPs). PPAPs are characterized by polycyclic and branched-chain substitutions in their structures, which make their structure types diverse. Moreover, they have been found to have antitumor, antiviral, antibacterial, anti-inflammatory and other biological activities. This research classified and summarized 344 polycyclic polyprenylated acylphloroglucinols from Hypericum plants in order to provide a scientific basis for further development and utilization of PPAPs from the genus.
