Prognostic Factors and Treatment Outcome for Thymoma.
- Author:
Hak Jae KIM
;
Charn Il PARK
;
Seong Soo SHIN
;
Joo Hyun KIM
;
Jeong Wook SEO
- Publication Type:Original Article
- MeSH:
Disease-Free Survival;
Drug Therapy;
Follow-Up Studies;
Humans;
Radiotherapy;
Retrospective Studies;
Seoul;
Sex Ratio;
Survival Rate;
Thymoma*;
Treatment Outcome*
- From:The Journal of the Korean Society for Therapeutic Radiology and Oncology
2001;19(4):306-311
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In this retrospective study, we attempted to evaluate the treatment outcome and the prognostic factors of thymoma treated with surgery, radiotherapy and chemotherapy. METHODS AND MATERIALS: Between 1979 and 1998, 55 patients with thymoma were treated at the Seoul National University Hospital. Of these, 11 patients underwent surgery only, 33 patients received postoperative radiotherapy and 11 patients received radiotherapy only. Twenty-three patients had gross total resection and 21 patients subtotal resection. For postoperative radiotherapy, the radiation dose consisted of 41.4-55.8 Gy. The average follow-up was 64 months, and ranged from 2 to 160 months. The sex ratio was 1:1 and the median age was 48 years (15-74 years). Overall survival and disease-free survival were determined via the Kaplan-Meier method, and the log-rank was employed to evaluate for differences in prognostic factor. RESULTS: The five- and 10-year survival rates were 87% and 65% respectively, and the median survival was 103 months. By univariate analysis, only stage ( p=0.0017) turned out to be significant prognostic factors of overall survival. Also, stage ( p=0.0007) was significantly predictive for overall survival in mutivariated analysis. CONCLUSION: This study showed the stage was found to be important prognostic factors, which influenced survival. Especially, as incomplete resection is related with poor results, complete resection is important to cure the invasive thymoma.
