Role of Vascular Aging in the Pathogenesis of Abdominal Aortic Aneurysm and Potential Therapeutic Targets.
10.3881/j.issn.1000-503X.13453
- Author:
Jian-Qiang WU
1
;
Wei WANG
2
;
Yue-Hong ZHENG
2
Author Information
1. Medical Research Center, PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
2. Department of Vascular Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Review
- Keywords:
abdominal aortic aneurysm;
aging;
drug targets;
pathogenesis
- MeSH:
Aged;
Aging;
Animals;
Aorta, Abdominal;
Aortic Aneurysm, Abdominal/drug therapy*;
Disease Models, Animal;
Humans;
Muscle, Smooth, Vascular/metabolism*;
Oxidative Stress
- From:
Acta Academiae Medicinae Sinicae
2021;43(6):962-968
- CountryChina
- Language:Chinese
-
Abstract:
Abdominal aortic aneurysm(AAA)is a common aortic degenerative disease in the elderly,and its incidence is gradually increasing with the aging of the population.There are no specific drugs available to delay the expansion of AAA.Once the aneurysm ruptures,the mortality will exceed 90%,which seriously threatens the life of patients.Given the high incidence of AAA in the elderly,this review discusses the role of vascular aging in the pathogenesis of AAA,involving chronic inflammation,oxidative stress,mitochondrial dysfunction,protein homeostasis imbalance,increased apoptosis and necrosis,extracellular matrix remodeling,nutritional sensing disorders,epigenetic changes,and increased pro-aging factors.Meanwhile,several potential aging-related drug targets of AAA are listed.This review provides new ideas for basic and translational medical research of AAA.
