Advances of the Regulation of microRNAs in Follicular Development.
10.3881/j.issn.1000-503X.12683
- Author:
Yan-Mei SUN
1
;
Xi-Yan WANG
1
;
Di WU
1
;
Xue-Nan WANG
2
;
Xiao-Yan PAN
1
Author Information
1. Center for Reproductive Medicine,Jilin Medical University,Jilin,Jilin 132013,China.
2. Reproductive Medicine Center of Affiliated Hospital of Jining Medical University,Jining,Shandong 272029,China.
- Publication Type:Journal Article
- Keywords:
follicular development;
granulosa cell;
hormone synthesis;
microRNAs;
oocyte
- MeSH:
Female;
Follicular Fluid;
Granulosa Cells;
Humans;
MicroRNAs/genetics*;
Oogenesis;
Ovarian Follicle
- From:
Acta Academiae Medicinae Sinicae
2021;43(5):815-821
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,microRNAs(miRNAs)have been detected at different stages of follicular development and in different cells of follicles.Extracellular vesicle(EV)-derived miRNAs have also been detected in the follicular fluid of mature follicles.miRNAs participate in the regulation of normal follicular development,and the regulation disorder may lead to the occurrence of some ovarian diseases.In order to further systematically elucidate the regulatory mechanism of miRNAs on follicular development and find suitable EV-derived miRNAs that can predict oocyte development,we reviewed the functions of miRNAs in follicular development from the perspectives of granulosa cell development,oocyte development,and hormone synthesis.
