Nucleotide-binding Oligomerization Domain-like Receptor Family Pyrin Domain Containing 3 Inflammasome in Alzheimer's Disease.
10.3881/j.issn.1000-503X.12585
- Author:
Yun-Ying FENG
1
;
Hui CHEN
2
Author Information
1. School of Basic Medicine,CAMS and PUMC,Beijing 100730,China.
2. Department of Immunology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China.
- Publication Type:Review
- Keywords:
Alzheimer's disease;
amyloid β protein;
microglia;
nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 inflammasome
- MeSH:
Alzheimer Disease;
Humans;
Inflammasomes;
Microglia;
NLR Family, Pyrin Domain-Containing 3 Protein;
Neurodegenerative Diseases;
Nucleotides;
Pyrin Domain
- From:
Acta Academiae Medicinae Sinicae
2021;43(5):788-795
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is a chronic neurodegenerative disease whose cause remains unclear.The β-amyloid plaques in the brain are one of the major pathological features of AD.However,the drugs targeting extracellular β-amyloid plaques have failed to cure the disease.Innate immunity and neuroinflammation play a role in the pathogenesis and progression of AD.As the macrophages existing in the central nervous system,microglia are related with extracellular β-amyloid deposition,intracellular neurofibrillary tangle formation,and neuron injury.Accumulating evidence demonstrates that the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3(NLRP3)inflammasome in microglia plays a role in AD,suggesting new therapeutic target for AD in this signaling pathway.This article reviewed the studies about the activation and regulation of NLRP3 inflammasome in the pathogenesis and progression of AD as well as the development of AD therapies targeting this pathway,aiming to provide reference for further studies in this field.
