Effects of Human Immunodeficiency Virus-positive Mothers Receiving Antiretroviral Therapy to Prevent Mother-to-child Transmission on the Growth and Development of 18-month-old Children in Lingshan County of Guangxi.
- Author:
Xian-Min GE
1
;
Mei LIN
1
;
Jin-Mei CHEN
2
;
Jin-Hui ZHU
1
;
Guang-Hua LAN
1
;
Yu YAN
3
;
Huan-Huan CHEN
1
;
Liu-Hong LUO
1
;
Shan-Shan LI
1
;
Bin LI
1
;
Guang-Hua HUANG
2
;
Jia-Wei LI
3
;
Yue-Qin DENG
4
;
Ping-Jing WEN
1
;
Yu-Man HUANG
1
;
Qiu-Ying ZHU
1
;
Qin MENG
1
;
Shuai-Feng LIU
1
;
Xiu-Ling WU
1
;
Jing-Hua HUANG
1
;
Hua-Xiang LU
1
Author Information
- Publication Type:Journal Article
- Keywords: antiretroviral therapy; growth and development; human immunodeficiency virus; prevention of mother-to-child transmission
- MeSH: Case-Control Studies; China/epidemiology*; Female; Growth and Development; HIV; HIV Infections/prevention & control*; Humans; Infant; Infectious Disease Transmission, Vertical/prevention & control*; Mothers; Pregnancy; Pregnancy Complications, Infectious/drug therapy*; Retrospective Studies
- From: Acta Academiae Medicinae Sinicae 2021;43(5):743-748
- CountryChina
- Language:Chinese
- Abstract: Objective To evaluate the effects of antiretroviral therapy(ART)for the prevention of mother-to-child transmission(PMTCT)of acquired immune deficiency syndrome(AIDS)on the growth and development of 18-month-old children born by human immunodeficiency virus(HIV)-positive pregnant women in Lingshan County,Guangxi Zhuang Autonomous Region,and provide scientific evidence for improving the ART medication plan for PMTCT.Methods Lingshan County,ranking the first in the HIV-epidemic counties of Guangxi,was selected as the research site.According to the design of retrospective case-control study,we assigned all the subjects into the case group and the control group:(1)The case group included the HIV-positive pregnant women who had received ART for PMTCT and their HIV-negative infants in Lingshan County from 2010 to 2017.The historical cards and PMTCT data of them were collected from the national PMTCT database.(2)The control group included the healthy pregnant women and their healthy babies born in the Lingshan Maternity and Infant Hospital in 2017,and the children's growth and development data were collected.The stunted growth in children was defined as at least one of the three main indicators of body height,body weight,and head circumference below the normal range.Results The number of HIV-positive mothers and their infants in the case group was 391 and 368,respectively,and 87.21%(341/391)and 95.38%(351/368)of mothers and infants respectively received ART medication.The HIV positive rate,mortality rate,and mother-to-child transmission rate of 18-month-old children were 1.36%(5/368),4.35%(16/368),and 2.01%(5/249),respectively.The incidence of stunted growth of 18-month-old children in the case group and the control group was 42.12%(155/368)and 23.06%(101/438),respectively,with significant difference(
