Differences of Gut Microbiota Diversity between Patients with Abdominal Aortic Aneurysm and Atherosclerosis.
10.3881/j.issn.1000-503X.13443
- Author:
Lei JI
1
;
Guang-Chao GU
1
;
Si-Liang CHEN
1
;
Wei WANG
1
;
Jin-Rui REN
1
;
Fang-da LI
1
;
Jian-Qiang WU
2
;
Dan YANG
3
;
Yue-Hong ZHENG
1
Author Information
1. Medical Research Center,PUMC Hospital, Department of Vascular Surgery,Beijing 100730,China.
2. Medical Research Center,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
3. Department of Computational Biology and Bioinformatics,Institute of Medicinal Plant Development, CAMS and PUMC,Beijing 100193,China.
- Publication Type:Journal Article
- Keywords:
16S rDNA;
abdominal aortic aneurysm;
atherosclerosis;
gut microbiota
- MeSH:
Aortic Aneurysm, Abdominal;
Atherosclerosis;
Feces;
Gastrointestinal Microbiome;
Humans
- From:
Acta Academiae Medicinae Sinicae
2021;43(5):677-684
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences of gut microbiota between patients with abdominal aortic aneurysm and atherosclerosis.Methods From December 2018 to June 2019,20 fresh stool samples were collected respectively from the patients with abdominal aortic aneurysm and atherosclerosis treated at the Department of Vascular Surgery,Peking Union Medical College Hospital.The 16S rDNA high-throughput sequencing was employed to compare the composition,abundance,and α and β diversities of gut microbiota between the two disease groups,and further determine the significantly differential genera.Results The two groups had great similarities in the composition of gut microbiota.There was no statistical difference in α diversity.Although β diversity did not have statistically significant difference,certain microbial taxa showed differences between the two groups.The LEfSe demonstrated that the abdominal aortic aneurysm group had higher relative abundance of
