Advances in the biosynthesis of pentostatin.

Author: Zeqi SONG ¹ ; Huhu LIU ¹ ; Xiyu DUAN ¹ ; Hui YANG ¹ ; Chong WANG ¹ ; Xiangyang LU ¹ ; Yun TIAN ¹
Author Information

1. College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, Hunan, China.
Publication Type:Review
Keywords: biosynthesis; microbial fermentation; nucleoside antibiotics; pentostatin; systems metabolic engineering
MeSH: Anti-Bacterial Agents; Pentostatin
From: Chinese Journal of Biotechnology 2021;37(12):4158-4168
CountryChina
Language:Chinese
Abstract: Pentostatin is a nucleoside antibiotics with a strong inhibitory effect on adenosine deaminase, and is widely used in the clinical treatment of malignant tumors. However, the high cost hampers its application. In the past 10 years, the biosynthesis of pentostatin were focused on strain breeding, optimization of medium composition and fermentation process. To date, there are no reviews summarizing the elucidated biosynthetic mechanism of pentostatin. This review starts by introducing the various chemical route for production of pentostatin, followed by summarizing the mechanisms of pentostatin biosynthesis in different microorganisms. Finally, challenges for biosynthesis of pentostatin were discussed, and strategies for regulating and improving the microbial synthesis of pentostatin were proposed.