Induction and differentiation of induced pluripotent stem cells into macrophages: a review.

Author: Xinchun YANG ¹ ; Xiaolong WU ¹ ; Jinlian HUA ¹
Author Information

1. Shaanxi Stem Cell Engineering and Technology Research Center, College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling 712100, Shaanxi, China.
Publication Type:Review
Keywords: cell differentiation; embryoid bodies induction; iPSCs; macrophages; monolayer cell induction; organoid co-culture
MeSH: Cell Differentiation; Embryonic Stem Cells; Induced Pluripotent Stem Cells; Macrophages
From: Chinese Journal of Biotechnology 2021;37(11):4001-4014
CountryChina
Language:Chinese
Abstract: Induced pluripotent stem cells (iPSCs) are a type of cells similar to embryonic stem cells but produced by reprogramed somatic cells. Through in vitro differentiation of iPSCs, we can interrogate the evolution history as well as the various characteristics of macrophages. iPSCs derived macrophages are not only a good model for drug screening, but also an important approach for immunotherapy. This review summarizes the advances, challenges, and future directions in the field of iPSCs-derived macrophages.