Advances of Kunitz-type serine protease inhibitors.
- Author:
Yunyang LIU
1
;
Shuai JIANG
1
;
Qian LI
1
;
Yi KONG
1
Author Information
- Publication Type:Journal Article
- Keywords: Kunitz domain; blood coagulation balance; immune regulation; infection; inflammatory response; protease inhibitors
- MeSH: Protease Inhibitors; Serine Proteases; Serine Proteinase Inhibitors
- From: Chinese Journal of Biotechnology 2021;37(11):3988-4000
- CountryChina
- Language:Chinese
- Abstract: Kunitz-type serine protease inhibitors are a class of ubiquitous protease inhibitors, which play important roles in various life activities. The structures of such inhibitors are generally stable, and are usually characterized by the presence of one or several Kunitz domains in tandem, which are able to bind to serine proteases in a manner similar to substrate binding, thereby inhibiting enzyme activity. In terms of function, Kunitz-type serine protease inhibitors are involved in processes such as blood coagulation and fibrinolysis, tumor immunity, inflammation regulation, and resistance to bacterial and fungal infections. This article summarizes the advances of Kunitz-type serine protease inhibitors and provides new ideas for the development of novel Kunitz-type serine protease inhibitors.
