Vaginal microbiome: community characteristics and disease intervention.

Author: Hulin LIU ¹ ; Xingran XU ¹ ; Kaijian LING ² ; Xiang ZOU ¹
Author Information

1. College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
2. Department of Obstetrics and Gynecology, The first Affiliates Hospital of Army Military Medical University, Chongqing 400038, China.
Publication Type:Journal Article
Keywords: engineered probiotics; flora intervention; genital tract diseases; vaginal microbiome
MeSH: Female; Humans; Microbiota; Probiotics; Vagina
From: Chinese Journal of Biotechnology 2021;37(11):3801-3811
CountryChina
Language:Chinese
Abstract: The application of high-throughput sequencing technologies has greatly enhanced our understanding to the human microbiome. The causal relations between human microbiome and diseases have become a critical issue to elucidate disease development and develop precision medicine. Recently, the study about vaginal microbiome (the microbial flora that inhabits the female vagina) has received wide interests. It has been shown that dysbiosis of vaginal microbiome was closely related to the development of genital tract diseases. This article summarizes the interaction between vaginal microbiome and disease and the treatment for the dysbiosis of vaginal microbiome. The culturomics of virginal microbiome, engineered probiotics and synthetic microbiome were also proposed.