Advances in the release mechanisms of bluetongue virus.

Author: Junhong LIN ¹ ; Rang WANG ¹ ; Yao ZHAO ¹ ; Yujuan CHEN ¹ ; Xianping MA ¹ ; Huashan YI ¹
Author Information

1. College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Publication Type:Review
Keywords: NS3 protein; bluetongue virus; extracellular vesicles; lytic release; non-lytic release
MeSH: Animals; Bluetongue; Bluetongue virus; Ceratopogonidae; Sheep; Viral Nonstructural Proteins
From: Chinese Journal of Biotechnology 2021;37(9):3179-3189
CountryChina
Language:Chinese
Abstract: Bluetongue virus (BTV) causes Bluetongue (BT) of ruminants vectored by culicoides midges. It is also a classic model for studying the release mechanism of non-enveloped virus. This review begins with the infection and assembly of BTV, then summarizes the advances of different ways of releasing BTV. This includes BTV-induced autophagy and the release as extracellular vesicles via multivesicular bodies, BTV-induced apoptosis and the lytic release, as well as different pathways of release through budding via plasma membrane. The regulatory mechanisms of NS3 which is a key non-structural protein during the release of BTV are also discussed, providing a basis for further understanding the molecular mechanisms underpinning the infection, proliferation and release of BTV.