Advances in biodegradation of macrolide antibiotics.

Author: Yulong YUAN ¹ ; Dongmei LIU ² ; Rongcheng XIANG ¹ ; Zhenzhen LI ¹ ; Meng ZHANG ¹ ; Jian ZHAO ³ ; Bo FAN ¹ ; Chunyu LI ² ; Dongze NIU ² ; Jianjun REN ²
Author Information

1. School of Pharmacy, Changzhou University, Changzhou 213614, Jiangsu, China.
2. Urban and Rural Mine Research Institute, Changzhou University, Changzhou 213614, Jiangsu, China.
3. Guangzhou Institute of Criminal Science and Technology, Public Security Bureau of Guangzhou Municipality, Guangzhou 510030, Guangdong, China.
Publication Type:Review
Keywords: antibiotic residues; degradation; macrolide antibiotics; microorganisms
MeSH: Anti-Bacterial Agents; Biodegradation, Environmental; Macrolides
From: Chinese Journal of Biotechnology 2021;37(9):3129-3141
CountryChina
Language:Chinese
Abstract: Macrolide antibiotics are a class of broad-spectrum antibiotics with the macrolide as core nucleus. Recently, antibiotic pollution has become an important environmental problem due to the irregular production and abuse of macrolide antibiotics. Microbial degradation is one of the most effective methods to deal with antibiotic pollution. This review summarizes the current status of environmental pollution caused by macrolide antibiotics, the degradation strains, the degradation enzymes, the degradation pathways and the microbial processes for degrading macrolide antibiotics. Moreover, the critical challenges on the biodegradation of macrolide antibiotics were also discussed.