Abnormal static and dynamic brain function in patients with temporomandibular disorders: a resting-state functional magnetic resonance imaging study.
- Author:
Yuan Yuan YIN
1
;
Fei LI
2
;
Shu Shu HE
1
;
Song CHEN
1
Author Information
- Publication Type:Journal Article
- Keywords: brain function; dynamic amplitude of low frequency fluctuation; resting-state functional magnetic resonance imaging; static amplitude of low frequency fluctuation; temporomandibular disorders
- MeSH: Brain/diagnostic imaging*; Humans; Magnetic Resonance Imaging; Temporomandibular Joint Disorders/diagnostic imaging*
- From: West China Journal of Stomatology 2021;39(6):682-689
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:This study was conducted to investigate the brain function of patients with temporomandibular disorders (TMD) by combining the static and dynamic amplitudes of low-frequency fluctuation (ALFF).
METHODS:Thirty patients with TMD and 20 healthy controls were enrolled. All the participants completed their questionnaires, received clinical examinations, and underwent resting-state functional magnetic resonance imaging scanning. We compared the static and dynamic ALFF between the patients and healthy controls by conducting a two-sample
RESULTS:The patients with TMD showed increased static and dynamic ALFF in the posterior cingulate cortex compared with that of the controls (whole-brain level, uncorrected
CONCLUSIONS:Our findings revealed that the resting-state brain function of the posterior cingulate cortex and the medial orbitofrontal cortex of patient with TMD increased. These changes probably indicated the potential central mechanisms underlying the increased self-relevant thoughts, negative emotion, and abnormal emotion regulation in TMD.
