Research progress on the application of framework nucleic acid in bone regeneration.

Author: Yun Feng LIN ¹
Author Information

1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
Keywords: DNA nanostructure; bone regeneration; framework nucleic acid; tissue engineering
MeSH: Bone Regeneration; Nanostructures; Nanotechnology; Nucleic Acids; Osteogenesis; Tissue Engineering
From: West China Journal of Stomatology 2021;39(6):624-632
CountryChina
Language:English
Abstract: Framework nucleic acid (FNA) is a set of DNA nanostructures characterized by the framework morphology. It can design rational DNA sequences and follow the principle of complementary base pairing to construct FNA. The recent discovery of FNA constructed by DNA nanotechnology has great application potential in the field of bone regene-ration. It plays a positive role in the osteogenic differentiation of stem cells, bone regeneration, vascular regeneration, neuromodulation, immune regulation, and drug delivery. Here, we reviewed the current study findings on FNA in the field of bone regeneration.