Application of platelet-rich fibrin on mandibular third molar extraction: systematic review and Meta-analysis.

Ming-zhe Bao; Wei Liu; Shu-rong YU; Yi Men; Bo Han; Chun-jie LI

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Application of platelet-rich fibrin on mandibular third molar extraction: systematic review and Meta-analysis.

Author: Ming-Zhe BAO ¹ ; Wei LIU ¹ ; Shu-Rong YU ² ; Yi MEN ¹ ; Bo HAN ¹ ; Chun-Jie LI ¹
Author Information

1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
2. Dept. of Stomatology, Hospital of Traditional Chinese Medicine Affiliated to Southwest Medical University, Luzhou 646000, China.
Publication Type:Systematic Review
Keywords: Meta-analysis; mandibular third molar extraction; platelet-rich fibrin; systematic review
MeSH: Humans; Mandible; Molar, Third/surgery*; Platelet-Rich Fibrin; Tooth Extraction; Tooth, Impacted
From: West China Journal of Stomatology 2021;39(5):605-611
CountryChina
Language:English
Abstract: OBJECTIVES:This study aims to analyze the effectiveness of platelet-rich fibrin (PRF) in mandibular third molar extraction and provide suggestions for alleviating postoperative complications.
METHODS:Pubmed, EMBASE, Web of Science, and SinoMed were searched electronically on February 2020. Randomized controlled trials focusing on PRF usage in mandibular third molar extraction were included. Reviewers assessed the risk of bias in the included literature and extracted data independently using the criteria recommended by the Cochrane Collaboration. Meta-analysis was performed using RevMan 5.3 and STATA 13.0.
RESULTS:Twenty-one studies were included, comprising 991 patients who had mandibular third molar extraction. The topical application of PRF effectively reduced pain after extraction [MD=-12.06, 95%CI (-21.42, -2.71),
CONCLUSIONS:Limited clinical evidence indicates that applying PRF after mandibular third molar extraction could reduce pain, swelling, trismus and the occurrence of dry socket and promote soft tissue healing. However, the effect of PRF on bone healing requires further large-scale randomized controlled trials and unified measurement criteria.