Detection of peripheral blood circulating tumor cells in oral squamous cell carcinoma and its clinical significance.
- Author:
Shuai-Yuan ZHANG
1
;
Shuo QIN
1
;
Guang-Hui LI
1
;
Ya-Qun YI
1
;
Hao-Jie FU
1
;
Ya-Jing GAO
1
;
Ming-Lei SUN
1
Author Information
- Publication Type:Journal Article
- Keywords: circulating tumor cells; liquid biopsy; oral squamous cell carcinoma
- MeSH: Carcinoma, Squamous Cell/diagnosis*; Head and Neck Neoplasms; Humans; Mouth Neoplasms/diagnosis*; Neoplastic Cells, Circulating; Squamous Cell Carcinoma of Head and Neck
- From: West China Journal of Stomatology 2021;39(5):591-597
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:This study aims to investigate the diagnostic value of peripheral blood circulating tumor cells (CTCs) in oral squamous cell carcinoma (OSCC) and its correlation with the clinicopathological features of OSCC.
METHODS:Ninety-three patients diagnosed as OSCC in the First Affiliated Hospital of Zhengzhou University from May 2019 to May 2020 were selected as the experimental group, and 20 healthy volunteers were employed as the control group. The CTCs value of peripheral blood of the patients were measured by CTCs detection technology, and its clinical significance was analyzed.
RESULTS:The CTCs values in the experimental group were higher than those in the control group, and the difference was statistically significant (
CONCLUSIONS:Peripheral blood CTCs has important clinical value for early screening, auxiliary diagnosis, evaluation of metastasis, and determination of malignant degree, progression, and pathological grade of OSCC and a relatively reliable tumor detection indicator.
