Effects of different irradiators on the establishment of osteoradionecrosis model of rat mandible.
- Author:
Hua-Wei CHEN
1
;
Sheng-Fu ZHANG
1
;
Hai-Tao HE
1
Author Information
- Publication Type:Journal Article
- Keywords: linear accelerator; model; osteoradionecrosis of jaw; small-animal irradiator
- MeSH: Animals; Mandible; Molar; Osteoradionecrosis/etiology*; Rats; Rats, Sprague-Dawley; X-Ray Microtomography
- From: West China Journal of Stomatology 2021;39(5):524-530
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To compare the effects of different irradiators on the establishment of osteoradionecrosis of jaw model (ORNJ) to explore an ideal modeling method.
METHODS:A total of 33 adult SD rats were included and randomly divided into three groups according to the radiation equipment, namely, the blank control (CN, 3 rats), group A (linear accelerator irradiation, 15 rats), and group B (small-animal irradiator irradiation, 15 rats). Groups A and B were irradiated with daily fractions of 7, 8, and 9 Gy for 5 days and further divided into three subgroups as follows: group A
RESULTS:At 3 weeks after dental extractions, complete gingival healing was found in the regions of dental extractions in groups A
CONCLUSIONS:Small-animal irradiator irradiation is an ideal device for establishing ORNJ model.
