Effect of peroxisome proliferator-activated receptor-γ coactivator-1α on liver injury induced by periodontitis in rats.
- Author:
Bo-Yuan XIA
1
;
Yan LI
1
;
Xu DING
1
;
Xin LI
1
;
Xin-Chan LIU
2
;
Wei-Xian YU
2
Author Information
- Publication Type:Journal Article
- Keywords: liver injury; periodontitis; peroxisome proliferator-activated receptor-γ coactivator-1α
- MeSH: Animals; Liver/injuries*; Male; PPAR gamma; Periodontitis/pathology*; Rats; Rats, Wistar
- From: West China Journal of Stomatology 2021;39(5):518-523
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To investigate the effect of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) on liver injury induced by periodontitis in rats.
METHODS:Twenty-four male Wistar rats were randomly divided into two groups: control group and periodontitis group, twelve per group. In periodontitis group, the periodontitis models were established for the maxillary first molars in rats by means of "wire ligation+vaccinationwith
RESULTS:The probing depth, tooth mobility and sulcus bleeding index in periodontitis group were significantly higher than that in control group. HE staining showed in periodontitis group, hepatic cords ranged disorderly and there were vacuoles in cells and inflammatory cells infiltrated in liver tissues of rats, and there was no obvious abnormality in control group. The qRT-PCR results showed that the mRNA expression levels of
CONCLUSIONS:PGC-1α may be involved in the process of periodontitis-induced liver injury in rats.
