Effect of RhoE expression on the migration and invasion of tongue squamous cell carcinoma.

Kai Zhao; Wen-hong Yuan; Wen-jian LI; Zeng-peng Chi; Shao-ru Wang; Zheng-gang Chen

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Effect of RhoE expression on the migration and invasion of tongue squamous cell carcinoma.

Author: Kai ZHAO ¹ ; Wen-Hong YUAN ² ; Wen-Jian LI ³ ; Zeng-Peng CHI ⁴ ; Shao-Ru WANG ³ ; Zheng-Gang CHEN ²
Author Information

1. School of Stomatology, Qingdao University, Qingdao 266003, China.
2. Dept. of Stomatology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China.
3. School of Stomatology, Dalian Medical University, Dalian 116044, China.
4. College of Stomatology, Weifang Medical University, Weifang 261021, China.
Publication Type:Journal Article
Keywords: RhoE; invasion; migration; tongue squamous cell carcinoma
MeSH: Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Tongue; Tongue Neoplasms; rho GTP-Binding Proteins/genetics*; rho-Associated Kinases
From: West China Journal of Stomatology 2021;39(5):510-517
CountryChina
Language:English
Abstract: OBJECTIVES:This study aims to investigate the effect of RhoE expression on the migration and invasion of tongue squamous cell carcinoma (TSCC).
METHODS:Forty-eight TSCC cases were selected from the Maxillofacial Surgery Center of Qingdao Municipal Hospital from 2017 to 2019. The expression of RhoE in the specimens (TSCC and adjacent tissues) was detected by immunohistochemistry, and RhoE mRNA and protein were extracted to further detect the expression of RhoE. SCC-4 and CAL-27 cells were selected for
RESULTS:The expression level of RhoE in TSCC was significantly lower than that in adjacent tissues (
CONCLUSIONS:RhoE expression is low in TSCC. Over expression RhoE in TSCC can significantly decrease its migration and invasion abilities. Hence, RhoE may play an important role in regulating the metastasis and invasion of TSCC and provide a new target for gene therapy.