Association of Serum Glucocorticoids with Various Blood Pressure Indices in Patients with Dysglycemia and Hypertension: the Henan Rural Cohort Study.

Yuan XUE; Zhen Xing MAO; Xue LIU; Dan Dan WEI; Chang LIU; Shan Bin PANG; Song Cheng YU; Jiao Jiao GAO; Ji Song LIN; Dong Dong ZHANG; Chong Jian WANG; Wen Jie LI; Xing LI

Return

Association of Serum Glucocorticoids with Various Blood Pressure Indices in Patients with Dysglycemia and Hypertension: the Henan Rural Cohort Study.

Author: Yuan XUE ¹ ; Zhen Xing MAO ² ; Xue LIU ² ; Dan Dan WEI ² ; Chang LIU ³ ; Shan Bin PANG ¹ ; Song Cheng YU ¹ ; Jiao Jiao GAO ¹ ; Ji Song LIN ¹ ; Dong Dong ZHANG ¹ ; Chong Jian WANG ² ; Wen Jie LI ¹ ; Xing LI ¹
Author Information

1. Department of Nutrition and Food Hygiene, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
2. Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
3. Department of Clinincal Nutrition, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.
Publication Type:Journal Article
Keywords: Blood pressure; Chinese rural; Dysglycemia with hypertension; Glucocorticoids
MeSH: Adult; Aged; Aged, 80 and over; Blood Pressure; Case-Control Studies; China/epidemiology*; Cohort Studies; Female; Glucocorticoids/blood*; Glycemic Load; Humans; Hydrocortisone/blood*; Hypertension/etiology*; Male; Middle Aged; Prevalence; Risk Factors; Rural Population; Young Adult
From: Biomedical and Environmental Sciences 2021;34(12):952-962
CountryChina
Language:English
Abstract: Objective:To our knowledge, no definitive conclusion has been reached regarding the relationship between glucocorticoids and hypertension. Here, we aimed to explore the characteristics of glucocorticoids in participants with dysglycemia and hypertension, and to analyze their association with blood pressure indicators.
Methods:The participants of this study were from the Henan Rural Cohort study. A total of 1,688 patients 18-79 years of age were included in the matched case control study after application of the inclusion and exclusion criteria. Statistical methods were used to analyze the association between glucocorticoids and various indices of blood pressure, through approaches such as logistic regression analysis, trend tests, linear regression, and restricted cubic regression.
Results:The study population consisted of 552 patients with dysglycemia and hypertension (32.7%). The patients with co-morbidities had higher levels of serum cortisol (
Conclusions:Serum deoxycortisol was positively correlated with systolic blood pressure, pulse pressure, mean arterial pressure, mean blood pressure, and mean proportional arterial pressure. Glucocorticoids (deoxycortisol and cortisol) increase the risk of hypertension in people with dysglycemia, particularly in those with T2DM.