Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults.

Bing WU; Yue Bin LYU; Zhao Jin CAO; Yuan WEI; Wan Ying SHI; Xiang GAO; Jin Hui ZHOU; Virginia Byers KRAUS; Feng ZHAO; Xin CHEN; Feng LU; Ming Yuan ZHANG; Ying Chun LIU; Qi Yue TAN; Shi Xun SONG; Ying Li QU; Xu Lin ZHENG; Chong SHEN; Chen MAO; Xiao Ming SHI

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Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults.

Author: Bing WU ^{1
,

2} ; Yue Bin LYU ³ ; Zhao Jin CAO ³ ; Yuan WEI ^{4
,

5} ; Wan Ying SHI ³ ; Xiang GAO ⁶ ; Jin Hui ZHOU ³ ; Virginia Byers KRAUS ⁷ ; Feng ZHAO ³ ; Xin CHEN ^{4
,

5} ; Feng LU ⁸ ; Ming Yuan ZHANG ^{4
,

5} ; Ying Chun LIU ³ ; Qi Yue TAN ^{4
,

5} ; Shi Xun SONG ³ ; Ying Li QU ³ ; Xu Lin ZHENG ³ ; Chong SHEN ⁹ ; Chen MAO ¹⁰ ; Xiao Ming SHI ^{1
,

2}
Author Information

1. Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China
2. China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
3. China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
4. China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China
5. School of Public Health, Jilin University, Changchun 130012, Jilin, China.
6. Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, 19019, USA.
7. Duke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, North Carolina, 27701, USA.
8. Beijing Municipal Health Commission Information Center, Beijing 100034, China.
9. Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China.
10. Division of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
Publication Type:Journal Article
Keywords: Calf circumference; Cognitive impairment; Handgrip strength; Older adults; Sarcopenia
MeSH: Aged; Aged, 80 and over; China/epidemiology*; Cognitive Dysfunction/etiology*; Female; Hand Strength; Humans; Leg/anatomy & histology*; Logistic Models; Male; Sarcopenia/pathology*
From: Biomedical and Environmental Sciences 2021;34(11):859-870
CountryChina
Language:English
Abstract: Objective:To evaluate the associations of sarcopenia, handgrip strength and calf circumference with cognitive impairment among Chinese older adults.
Methods:Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study. Cognitive impairment was assessed by the Chinese Mini-Mental State Examination. Handgrip strength was calculated from the means of the right and left hand values. Calf circumference was measured at the site of maximum circumference of the non-dominant leg. The formula developed by Ishii was used to define sarcopenia. Multiple logistic regression was performed to evaluate the associations of sarcopenia, handgrip strength, and calf circumference with cognitive impairment.
Results:The prevalence of cognitive impairment was 34.36%. The adjusted odds ratio (
Conclusion:Sarcopenia, identified by low handgrip strength and low calf circumference, was positively associated with cognitive impairment.