Association of Visit-to-Visit Variabilities in Metabolic Factors with Chronic Kidney Disease in Chinese Adults Living in Shanghai.
- Author:
Ling LI
1
;
Fei WANG
1
;
Min XU
2
,
3
;
Jie Li LU
2
,
3
;
Zhi Yun ZHAO
2
,
3
;
Mian LI
2
,
3
;
Tian Ge WANG
2
,
3
;
Shuang Yuan WANG
2
,
3
;
Yu Fang BI
2
,
3
;
Yu XU
2
,
3
;
Wei Min CAI
1
;
Guang NING
2
,
3
,
4
Author Information
- Publication Type:Journal Article
- Keywords: Chronic kidney disease; Cohort; Metabolic factor; Visit-to-visit variability
- MeSH: Aged; Aged, 80 and over; China/epidemiology*; Cohort Studies; Female; Glomerular Filtration Rate; Humans; Incidence; Male; Middle Aged; Renal Insufficiency, Chronic/physiopathology*
- From: Biomedical and Environmental Sciences 2021;34(10):761-772
- CountryChina
- Language:English
-
Abstract:
Objective:This study aimed to examine the association of visit-to-visit variabilities in metabolic factors with chronic kidney disease (CKD) in Shanghai community residents.
Methods:We used data from a cohort study of community residents who participated in three examinations in 2008, 2009, and 2013, respectively. Fasting plasma glucose (FPG) level, blood pressure (BP), and lipid levels were determined in 2,109 participants at all three visits, and CKD was evaluated between the second and the third visits. Visit-to-visit variabilities in metabolic factors were described by coefficients of variation (CV) at three visits. A variability score was calculated by adding the numbers of metabolic factors with a high variability defined as the highest quartile of CV. CKD was defined as the estimated glomerular filtration rate < 60 mL/min per 1.73 m
Results:A total of 200 (9.5%) participants had CKD at the third visit. Compared with the lowest quartile of CV, the highest quartile was associated with a 70% increased risk of CKD for FPG [odds ratio,
Conclusion:The visit-to-visit variabilities in metabolic factors were significantly associated with the risks of CKD in Shanghai community residents.
