Exosomal microRNAs: an emerging player in systemic lupus erythematosus.
- Author:
Xiao-Qi SHA
1
;
Xing-Yu GE
1
;
Yi JIN
1
;
Tian CHEN
1
;
Juan JI
1
;
Zhi-Feng GU
2
Author Information
1. Department of Stomatology, Affiliated Hospital of Nantong University, Nantong 226000, China.
2. Department of Stomatology, Affiliated Hospital of Nantong University, Nantong 226000, China. guzf@ntu.edu.cn.
- Publication Type:Review
- MeSH:
Cell Communication;
Exosomes/genetics*;
Humans;
Lupus Erythematosus, Systemic/genetics*;
MicroRNAs/genetics*
- From:
Acta Physiologica Sinica
2021;73(6):1035-1042
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are nanometer-sized membranous extracellular vesicles that can be secreted by almost all types of cells in the body. Exosomes are involved in cell-to-cell communication through autocrine and paracrine forms. Exosomal microRNAs (miRNAs) are stable in plasma, urine and other body fluids, and have various biological functions. They play an irreplaceable role in the occurrence, development, immune regulation of systemic lupus erythematosus (SLE). Recent studies have proposed that exosomal miRNAs have promising application prospects in the pathogenesis, early diagnosis, and treatment of SLE. Therefore, this review aims to introduce the current research progress on exosomal miRNAs in SLE and analyze their potential application value.
