PTK2B affects the levels of Aβ in blood and brain and behavioral functions via targeting LRP-1 transporter in Aβ-induced cognitive dysfunction mice.
- Author:
Kai-Min HAO
1
;
Zhen LIU
1
;
Hao-Yu WANG
1
;
Kun LI
1
;
Wen-Xiu QI
2
Author Information
1. Fenyang College of Shanxi Medical University, Fenyang 032200, China.
2. Fenyang College of Shanxi Medical University, Fenyang 032200, China. fycqwx@163.com.
- Publication Type:Journal Article
- MeSH:
Alzheimer Disease;
Amyloid beta-Peptides/metabolism*;
Animals;
Brain;
Cognitive Dysfunction/chemically induced*;
Disease Models, Animal;
Focal Adhesion Kinase 2;
Hippocampus/metabolism*;
Mice;
Mice, Inbred C57BL;
Peptide Fragments
- From:
Acta Physiologica Sinica
2021;73(5):845-854
- CountryChina
- Language:Chinese
-
Abstract:
The aim of the present study was to explore the correlation between ptk2b/PTK2B (protein tyrosine kinase 2 beta, a ptk2b-encoded protein) and the level of low density lipoprotein receptor-related protein-1 (LRP-1), as well as to uncover the relationship between the changes in beta amyloid protein (Aβ) levels in blood and brain and the expression of ptk2b in Aβ-induced cognitive dysfunction mice. A total of 64 3-month-old C57BL/6J mice were divided randomly into the experimental group and control group. All mice underwent the intracerebroventricular (i.c.v.) intubation. Mice in the experimental group received the i.c.v. infusion of oligomeric Aβ
