The role of FGF21 in the pathogenesis of cardiovascular disease.
10.1097/CM9.0000000000001890
- VernacularTitle:The role of FGF21 in the pathogenesis of cardiovascular disease
- Author:
Ying ZHANG
1
;
Dan LIU
1
;
Xiao-Xue LONG
1
;
Qi-Chen FANG
1
;
Wei-Ping JIA
1
;
Hua-Ting LI
1
Author Information
1. Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China.
- Publication Type:Review
- MeSH:
Cardiovascular Diseases;
Fibroblast Growth Factors;
Humans;
Lipid Metabolism;
Oxidative Stress
- From:
Chinese Medical Journal
2021;134(24):2931-2943
- CountryChina
- Language:English
-
Abstract:
The morbidity and mortality of cardiovascular diseases (CVDs) are increasing worldwide and seriously threaten human life and health. Fibroblast growth factor 21 (FGF21), a metabolic regulator, regulates glucose and lipid metabolism and may exert beneficial effects on the cardiovascular system. In recent years, FGF21 has been found to act directly on the cardiovascular system and may be used as an early biomarker of CVDs. The present review highlights the recent progress in understanding the relationship between FGF21 and CVDs including coronary heart disease, myocardial ischemia, cardiomyopathy, and heart failure and also explores the related mechanism of the cardioprotective effect of FGF21. FGF21 plays an important role in the prediction, treatment, and improvement of prognosis in CVDs. This cardioprotective effect of FGF21 may be achieved by preventing endothelial dysfunction and lipid accumulating, inhibiting cardiomyocyte apoptosis and regulating the associated oxidative stress, inflammation and autophagy. In conclusion, FGF21 is a promising target for the treatment of CVDs, however, its clinical application requires further clarification of the precise role of FGF21 in CVDs.
