Cognitive impairment in two subtypes of a single subcortical infarction.
10.1097/CM9.0000000000001938
- VernacularTitle:Cognitive impairment in two subtypes of a single subcortical infarction
- Author:
Tang YANG
1
;
Qiao DENG
2
;
Shuai JIANG
1
;
Yu-Ying YAN
1
;
Ye YUAN
1
;
Si-Miao WU
1
;
Shu-Ting ZHANG
1
;
Jia-Yu SUN
3
;
Bo WU
1
Author Information
1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
2. Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.
3. Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
- Publication Type:Journal Article
- MeSH:
Cerebral Infarction;
Cerebral Small Vessel Diseases;
Cognitive Dysfunction/etiology*;
Executive Function;
Humans;
Mental Status and Dementia Tests
- From:
Chinese Medical Journal
2021;134(24):2992-2998
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:Single subcortical infarction (SSI) is caused by two main etiological subtypes, which are branch atheromatous disease (BAD) and cerebral small vessel disease (CSVD)-related SSI. We applied the Beijing version of the Montreal Cognitive Assessment (MoCA-BJ), the Shape Trail Test (STT), and the Stroop Color and Word Test (SCWT) to investigate the differences in cognitive performance between these two subtypes of SSI.
METHODS:Patients with acute SSIs were prospectively enrolled. The differences of MoCA-BJ, STT, and SCWT between the BAD group and CSVD-related SSI group were analyzed. A generalized linear model was used to analyze the associations between SSI patients with different etiological mechanisms and cognitive function. We investigated the correlations between MoCA-BJ, STT, and SCWT using Spearman's correlation analysis and established cut-off scores for Shape Trail Test A (STT-A) and STT-B to identify cognitive impairment in patients with SSI.
RESULTS:This study enrolled a total of 106 patients, including 49 and 57 patients with BAD and CSVD-related SSI, respectively. The BAD group performances were worse than those of the CSVD-related SSI group for STT-A (83 [60.5-120.0] vs. 68 [49.0-86.5], P = 0.01), STT-B (204 [151.5-294.5] vs. 153 [126.5-212.5], P = 0.015), and the number of correct answers on Stroop-C (46 [41-49] vs. 49 [45-50], P = 0.035). After adjusting for age, years of education, National Institutes of Health Stroke Scale and lesion location, the performance of SSI patients with different etiological mechanisms still differed significantly for STT-A and STT-B.
CONCLUSIONS:BAD patients were more likely to perform worse than CSVD-related SSI patients in the domains of language, attention, executive function, and memory. The mechanism of cognitive impairment after BAD remains unclear.
