Usefulness of the CONUT index upon hospital admission as a potential prognostic indicator of COVID-19 health outcomes.
10.1097/CM9.0000000000001798
- Author:
Adrián K BENGELLOUN
1
;
Guillermo J ORTEGA
2
;
Julio ANCOCHEA
1
;
Ancor SANZ-GARCIA
2
;
Diego A RODRÍGUEZ-SERRANO
3
,
4
;
Guillermo FERNÁNDEZ-JIMÉNEZ
3
,
4
;
Rosa GIRÓN
1
;
Elena ÁVALOS
3
,
4
;
Joan B SORIANO
1
;
J Ignacio DE ULÍBARRI
3
,
4
Author Information
1. Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.
2. Unidad de Análisis de Datos, Instituto de Investigación Sanitaria del Hospital de la Princesa, Madrid, Spain.
3. Servicios de Neumología, Admisión y Documentación Clínica, Cuidados Intensivos y Nutrición y Dietética
4. Hospital Universitario de La Princesa, Madrid, Spain.
- Publication Type:Observational Study
- MeSH:
Aged;
Aged, 80 and over;
COVID-19;
Female;
Hospitalization;
Hospitals;
Humans;
Middle Aged;
Nutrition Assessment;
Nutritional Status;
Outcome Assessment, Health Care;
Prognosis;
Retrospective Studies;
SARS-CoV-2
- From:
Chinese Medical Journal
2021;135(2):187-193
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:In-hospital mortality in patients with coronavirus disease 2019 (COVID-19) is high. Simple prognostic indices are needed to identify patients at high-risk of COVID-19 health outcomes. We aimed to determine the usefulness of the CONtrolling NUTritional status (CONUT) index as a potential prognostic indicator of mortality in COVID-19 patients upon hospital admission.
METHODS:Our study design is of a retrospective observational study in a large cohort of COVID-19 patients. In addition to descriptive statistics, a Kaplan-Meier mortality analysis and a Cox regression were performed, as well as receiver operating curve (ROC).
RESULTS:From February 5, 2020 to January 21, 2021, there was a total of 2969 admissions for COVID-19 at our hospital, corresponding to 2844 patients. Overall, baseline (within 4 days of admission) CONUT index could be scored for 1627 (57.2%) patients. Patients' age was 67.3 ± 16.5 years and 44.9% were women. The CONUT severity distribution was: 194 (11.9%) normal (0-1); 769 (47.2%) light (2-4); 585 (35.9%) moderate (5-8); and 79 (4.9%) severe (9-12). Mortality of 30 days after admission was 3.1% in patients with normal risk CONUT, 9.0% light, 22.7% moderate, and 40.5% in those with severe CONUT (P < 0.05). An increased risk of death associated with a greater baseline CONUT stage was sustained in a multivariable Cox regression model (P < 0.05). An increasing baseline CONUT stage was associated with a longer duration of admission, a greater requirement for the use of non-invasive and invasive mechanical ventilation, and other clinical outcomes (all P < 0.05). The ROC of CONUT for mortality had an area under the curve (AUC) and 95% confidence interval of 0.711 (0.676-0746).
CONCLUSION:The CONUT index upon admission is potentially a reliable and independent prognostic indicator of mortality and length of hospitalization in COVID-19 patients.
