Elimination of hepatitis B virus infection in children: experience and challenge in China.
10.1097/CM9.0000000000001791
- Author:
Jie TANG
1
;
Yu-Qian LUO
2
;
Yi-Hua ZHOU
2
Author Information
1. Department of Obstetrics and Gynecology, Wujin Hospital Affiliated with Jiangsu University, Changzhou, Jiangsu 213017, China.
2. Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
- Publication Type:Journal Article
- MeSH:
China/epidemiology*;
Female;
Hepatitis B/prevention & control*;
Hepatitis B Surface Antigens;
Hepatitis B virus;
Hepatitis B, Chronic/prevention & control*;
Humans;
Infant;
Infant, Newborn;
Infectious Disease Transmission, Vertical/prevention & control*;
Pregnancy;
Pregnancy Complications, Infectious/epidemiology*
- From:
Chinese Medical Journal
2021;134(23):2818-2824
- CountryChina
- Language:English
-
Abstract:
Chronic hepatitis B virus (HBV) infection is a serious health issue because of its severe sequelae. Prevention of mother-to-child transmission (MTCT) of HBV is critical to eliminate chronic HBV infection. Here, we reviewed the progress toward the elimination of HBV infection in children in China in the recent decade. A universal hepatitis B vaccination program started from 2002 has been intensified, with the coverage of timely birth dose >95% of all newborn infants from 2012. Since 2011, China has taken a nationwide program to administer hepatitis B immunoglobulin (HBIG) with free of charge in all neonates of HBV-infected mothers, leading to a significant increment of timely use of HBIG. The prevalence of hepatitis B surface antigen (HBsAg) was declined from around 10% among children in 1980s to <0.5% among children born after 2011. Administration of oral antiviral agents in HBV-infected pregnant women with HBV DNA >2 × 105 U/mL during the third trimester is increasing, which will further reduce MTCT of HBV. However, there are some challenges in the elimination of HBV infection in children, which need to overcome by the concerted efforts. Nevertheless, it is anticipated that China will achieve the goal set by the World Health Organization that the prevalence of HBsAg in children aged <5 years is ≤0.1% by 2030.
