Abdominal acupoint thread embedding therapy based on "brain-intestinal connection" for mild-to-moderate Alzheimer's disease and its effects on serum levels of APP and Aβ
10.13703/j.0255-2930.20201106-k0002
- Author:
Shu-Quan YANG
1
,
2
;
De-Hui FAN
3
;
Zhi-Xian YUAN
3
;
Mei-Yi SU
3
;
Zhen-Ning ZHANG
3
;
Ying LIN
3
;
Hu-Guang LIN
3
Author Information
1. Fifth Clinical Medical College of Guangzhou University of CM, Guangzhou 510095, Guangdong Province, China
2. Department of Acupuncture-Moxibustion, Second Hospital of TCM of Guangdong Province, Guangzhou 510095.
3. Department of Acupuncture-Moxibustion, Second Hospital of TCM of Guangdong Province, Guangzhou 510095.
- Publication Type:Randomized Controlled Trial
- Keywords:
Alzheimer's disease (AD);
abdominal acupuncture therapy;
amyloid precursor protein (APP);
randomized controlled trial (RCT);
theory of brain-intestinal connection;
β- amyloid protein1-42 (Aβ1-42)
- MeSH:
Acupuncture Points;
Alzheimer Disease/drug therapy*;
Amyloid beta-Peptides;
Amyloid beta-Protein Precursor;
Brain;
Donepezil;
Humans;
Peptide Fragments
- From:
Chinese Acupuncture & Moxibustion
2021;41(11):1231-1235
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the clinical efficacy of abdominal acupoint thread embedding therapy based on "brain-intestinal connection" combined with donepezil hydrochloride tablets and oral donepezil hydrochloride tablets alone for mild-to-moderate Alzheimer's disease (AD) and observe its effects on amyloid precursor protein (APP) and β-amyloid protein
METHODS:Sixty patients with AD were randomly divided into an observation group (30 cases, 3 cases dropped off) and a control group (30 cases, 3 cases dropped off). The patients in the control group were treated with donepezil hydrochloride tablets (5 mg per day); based on the treatment in the control group, the patients in the observation group were treated with abdominal acupoint thread embedding therapy at Zhongwan (CV 12), Xiawan (CV 10), Huaroumen (ST 24), Wailing (ST 26), Daheng (SP 15), etc., once every 10 days. Both groups were treated for 2 months. The mini-mental state examination (MMSE), Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog), activity of daily living scale (ADL), neuropsychiatric inventory questionnaire (NPI) as well as the serum levels of APP and Aβ
RESULTS:After treatment, the MMSE scores in the two groups were higher than those before treatment (
CONCLUSION:The abdominal acupoint thread embedding therapy based on the theory of "brain-intestinal connection" combined with donepezil hydrochloride tablets can improve cognitive function, self-care ability of daily life and mental behavior, and reduce the serum levels of APP and Aβ
