Experimental Aconitine Neuroretinopathy in Rabbit Eye.
- Author:
Jae Ki BAE
1
;
Jae Yong BAE
;
Jyung Sik KWAK
;
Sang Ha KIM
;
Kui Deock SEOUK
Author Information
1. Department of Ophthalmology, School of Medicine, Kyungpook University, Taegu, Korea.
- Publication Type:Original Article
- MeSH:
Aconitine*;
Asian Continental Ancestry Group;
Humans;
Nerve Fibers, Myelinated
- From:Journal of the Korean Ophthalmological Society
1988;29(2):337-345
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Toxic effects of Aconiti tuber, an important ingredient of Chinese medicinal preparation, have been encountered clinically. The chief bioactive and toxic constituent is the alkaloid aconitine. In this study histopathologic changes in the fine structures of rabbit eye by intravenously administered aconitine were examined with light and electron microscopes. The initial and most characteristic features observed in the histopathologic study were degenerative changes in the myelinated nerve fiber layer. So the effects of aconitine on the rabbit eye were primarily regarded as toxic neuropathy.
