Research advances in the formation mechanism of primary intrahepatic stones caused by biliary flora
10.3969/j.issn.1001-5256.2022.02.045
- VernacularTitle:胆道菌群导致原发性肝内胆管结石形成机理的研究进展
- Author:
Jiangping REN
1
;
Jinfei QIU
1
;
Yang ZOU
1
;
Xiaobei CAI
1
;
Chenglei XU
1
;
Jiang LI
1
Author Information
1. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
- Publication Type:Reviews
- Keywords:
Primary Intrahepatic Stones;
Biliary Flora;
Pathologic Processes
- From:
Journal of Clinical Hepatology
2022;38(2):477-482
- CountryChina
- Language:Chinese
-
Abstract:
Primary intrahepatic stones (PIS) is a refractory disease with a high incidence rate in southwest China, and some patients still require surgery again or even more times after initial treatment. Many studies in recent years have shown that some specific flora can colonize in the intrahepatic bile duct, leading to chronic infection and inflammation of the biliary system, and these specific types of flora, called "stone-causing flora", can produce metabolites such as β-glucuronidase and play an important role in the formation of pigmented stones. This article analyzes the role of stone-causing flora in the pathogenesis of PIS, so as to provide more treatment options for PIS patients.
