Research advances in the prevention and treatment of hepatic ischemia-reperfusion injury with traditional Chinese medicine components
10.3969/j.issn.1001-5256.2022.02.044
- VernacularTitle:中医药成分防治肝缺血再灌注损伤的研究进展
- Author:
Zhen LI
1
;
Yihao ZENG
2
;
Ke WANG
1
;
Kaiqiang WANG
1
;
Kexian YU
3
Author Information
1. Graduate School, Qinghai University, Xining 810016, China
2. First Department of Rehabilitation, Guangzhou Renai Tianhe Hospital, Guangzhou 510630, China
3. Medical College, Qinghai University, Xining 810016, China
- Publication Type:Reviews
- Keywords:
Liver Diseases;
Reperfusion Injury;
Drugs, Chinese Herbal;
Therapeutics
- From:
Journal of Clinical Hepatology
2022;38(2):471-476
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic ischemia-reperfusion injury (HIRI) is a very common complication of liver transplantation, liver resection, and shock. At present, many studies have been conducted on HIRI, but there is still a lack of drugs for radical treatment in clinical practice. Many factors, such as related cells, molecular mechanisms and signaling pathways, reactive oxygen species and oxidative stress response, nitric oxide, and mitochondria, mediate the development and progression of HIRI, which leads to the decline of patients' quality of life and even endangers their life safety. Based on the pathogenesis of HIRI and related articles, this article summarizes the research advances in the prevention and treatment of HIRI with traditional Chinese medicine components, so as to provide theoretical support for basic research and clinical research on HIRI.
