Role of sphingomyelinases in hepatocellular carcinoma
10.3969/j.issn.1001-5256.2022.02.042
- VernacularTitle:鞘磷脂酶在肝细胞癌中的作用
- Author:
Chun YAO
1
;
Guangfa ZHANG
1
;
Yingyu LE
1
;
Dewen MAO
2
;
Rongzhen ZHANG
2
;
Yin LIU
2
Author Information
1. Graduate School, Guangxi University of Chinese Medicine, Nanning 530222, China
2. First Ward of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
- Publication Type:Reviews
- Keywords:
Carcinoma, Hepatocellular;
Sphingolipids;
Ceramides
- From:
Journal of Clinical Hepatology
2022;38(2):461-465
- CountryChina
- Language:Chinese
-
Abstract:
Sphingomyelinases (SMase) are the main enzymes that regulate the signaling pathway of sphingomyelin and the metabolism of related products, and they are involved in the key steps of the complex metabolic process of sphingomyelin. In recent years, many studies have shown that SMase is involved in the biological processes such as cell cycle arrest, cell migration, and inflammation and promotes the development and progression of hepatocellular carcinoma by regulating the apoptosis and proliferation of tumor stem cells. SMase has an important potential biological value in the development, progression, diagnosis, and treatment of hepatocellular carcinoma. This article summarizes the exact role of SMase in the development and progression of hepatocellular carcinoma, in order to provide new ideas and strategies for the clinical treatment of hepatocellular carcinoma and the development of new drugs.
