Role of liver-resident natural killer cells in the development and progression of hepatocellular carcinoma
10.3969/j.issn.1001-5256.2022.02.041
- VernacularTitle:肝脏驻留自然杀伤细胞在肝细胞癌发生发展中的作用
- Author:
Junqi WANG
1
;
Feng XU
1
Author Information
1. Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China
- Publication Type:Reviews
- Keywords:
Carcinoma, Hepatocellular;
Killer Cells, Natural;
Immunotherapy
- From:
Journal of Clinical Hepatology
2022;38(2):457-460
- CountryChina
- Language:Chinese
-
Abstract:
Liver-resident natural killer (LrNK) cells, as a type of newly discovered tissue-resident natural killer cells, have a strong immune killing function. During the development and progression of hepatocellular carcinoma (HCC), the function of LrNK cells is impaired and such cells may promote the progression of HCC by upregulating the expression of related immune checkpoints. Based on the latest research, this article reviews the immune function of LrNK cells and their role in the development and progression of HCC, in order to explore the application prospect of these cells in HCC immunotherapy.
