Association between the Wnt signaling pathway and hepatic fibrosis

VernacularTitle:Wnt信号通路与肝纤维化的关系
Author: Qin FAN ¹ ; Hongjun LI ^{2
,

3} ; Xiaoxia LI ^{2
,

3} ; Yin YANG ^{2
,

3} ; Haiyan CHEN ^{2
,

3} ; Jiamao CHENG ¹
Author Information

1. Department of Human Anatomy, Basic Medical College of Dali University, Dali, Yunnan 671000, China
2. Department of Ultrasound, School of Clinical Medicine, Dali University
3. Department of Ultrasound, The Fourth People's Hospital of Yunnan Province, Dali, Yunnan 671000, China
Publication Type:Reviews
Keywords: Liver Cirrhosis; Wnt Signaling Pathway; Hepatic Stellate Cells; Kupffer Cells; Stem Cells
From: Journal of Clinical Hepatology 2022;38(2):443-447
CountryChina
Language:Chinese
Abstract: Hepatic fibrosis (HF) is a self-healing pathological process after all kinds of chronic liver injuries and can cause diseases such as liver cirrhosis and liver cancer. The Wnt signaling pathway is highly conserved in species evolution and widely exists in invertebrates and vertebrates, and many studies have confirmed that the Wnt signaling pathway is closely associated with the development and progression of HF. This article reviews the mechanisms of the classical and non-classical Wnt signaling pathways in regulating hepatic stellate cells, hepatic macrophages, and hepatic progenitor cells, so as to provide new ideas for subsequent studies on the mechanism of the Wnt signaling pathway in regulating HF and further exploration of therapeutic targets that can reverse HF.