Role of branched-chain amino acids in the development and progression of nonalcoholic fatty liver disease

VernacularTitle:支链氨基酸在非酒精性脂肪性肝病发生发展中的作用
Author: Xiaoqing XIE ^{1
,

2} ; Yaxian LIU ² ; Shun CHEN ^{1
,

2} ; Xiaohui YU ^{1
,

2}
Author Information

1. Department of Gastroenterology, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, China
2. Department of Gastroenterology, The Second Hospital of Lanzhou University, Lanzhou 730030, China
Publication Type:Reviews
Keywords: Non-Alcoholic Fatty Liver Disease; Amino Acids, Branched-Chain; Metabolism
From: Journal of Clinical Hepatology 2022;38(2):439-442
CountryChina
Language:Chinese
Abstract: Nonalcoholic fatty liver disease is a common chronic liver disease with the risk of progression to nonalcoholic hepatitis, liver fibrosis, and hepatocellular carcinoma. Nonalcoholic fatty liver disease has various pathogeneses, among which abnormal metabolism of branched-chain amino acids can induce oxidative stress, autophagy, and mitochondrial dysfunction in hepatocytes and is the most important mechanism in the development and progression of nonalcoholic fatty liver disease. This article reviews related research advances and analyzes the possible role of abnormal metabolism of branched-chain amino acids in the development and progression of nonalcoholic fatty liver disease, in order to improve clinical awareness and diagnosis.