Inherited metabolic diseases causing acute liver failure in children
10.3969/j.issn.1001-5256.2022.02.005
- VernacularTitle:可引起儿童急性肝衰竭的遗传代谢病
- Author:
Huan LIANG
1
;
Huiwen ZHANG
1
Author Information
1. Department of Pediatric Endocrinology and Genetic Metabolism, Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
- Publication Type:Discussions by Experts
- Keywords:
Liver Failure, Acute;
Genetic Diseases, Inborn;
Diagnosis
- From:
Journal of Clinical Hepatology
2022;38(2):273-277
- CountryChina
- Language:Chinese
-
Abstract:
Acute liver failure (ALF) in children has complex etiologies, among which inherited metabolic diseases account for a high proportion, especially in infants and young children. Inherited metabolic diseases are a group of congenital diseases with destruction of cell physiological function caused by metabolism-related gene mutations, with various types and diverse clinical manifestations. ALF is one of the serious complications caused by such diseases and is easily neglected due to a lack of specific manifestations. ALF caused by such etiologies should be identified as early as possible to reverse the progression of ALF and improve the prognosis of patients. This article summarizes the common inherited metabolic diseases that can cause ALF in children, in order to improve the awareness of such etiology among physicians.
