Diagnosis and treatment progress on pediatric ocular graft-versus-host disease
10.3969/j.issn.1674-7445.2022.02.015
- VernacularTitle:儿童眼移植物抗宿主病诊治进展
- Author:
Juejing CHEN
1
;
Yinglin LIAO
;
Lingyi LIANG
Author Information
1. Zhongshan Ophthalmic Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China
- Publication Type:Research Article
- Keywords:
Ocular graft-versus-host disease;
Child;
Hematopoietic stem cell transplantation;
Dry eye;
Immune response;
Inflammation;
Ciclosporine;
Glucocorticoid
- From:
Organ Transplantation
2022;13(2):253-
- CountryChina
- Language:Chinese
-
Abstract:
Ocular graft-versus-host disease is one of the common complications after hematopoietic stem cell transplantation. Dry eye is the main clinical manifestation. Severe complications, such as corneal ulcer perforation and ocular surface failure may occur along with the progression of ocular graft-versus-host disease, which affects the visual acuity and quality of life of the patients. At present, multiple international researches and clinical guidelines for adult ocular graft-versus-host disease have been available. Nevertheless, pediatric ocular graft-versus-host disease has captivated insufficient attention, and relevant basic data and diagnostic criteria are still lacking. Children possess limited capability to express ocular symptoms, and lack of cooperation in clinical examination. In addition, ophthalmologists have insufficient understanding of this disease, which collectively increase the risk of missing diagnosis and misdiagnosis. In this article, the research progress on the pathogenesis, incidence, risk factors, clinical manifestations, diagnosis and treatment of pediatric ocular graft-versus-host disease was reviewed, aiming to provide ideas for strengthening clinical trials and expanding basic research of this disease in children.
