Research progress on application of machine perfusion in quality maintenance of donor kidney from organ donation after citizen's death
10.3969/j.issn.1674-7445.2022.02.007
- VernacularTitle:机械灌注在公民逝世后器官捐献供肾质量维护方面的应用研究进展
- Author:
Sheng CHANG
1
;
Linrui DAI
Author Information
1. Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
- Publication Type:Research Article
- Keywords:
Kidney transplantation;
Organ donation after citizen's death;
Expanded criteria donor;
Hypothermic machine perfusion (HMP);
Ex vivo normothermic perfusion (EVNP);
Abdominal regional perfusion (ARP);
Static cold storage (SCS);
Extracorporeal membrane oxygenation
- From:
Organ Transplantation
2022;13(2):195-
- CountryChina
- Language:Chinese
-
Abstract:
Organ donation after citizen's death has become the main source of organ donation in China. However, the complexity of donor quality and the increasing proportion of expanded criteria donor (ECD) exert significant impact upon the availability of donor kidney and the long-term prognosis of recipients after kidney transplantation. Strengthening the quality maintenance and evaluation of donor kidney is of great significance for improving the quality of donor kidney, increasing the procurement and utilization of donor kidney and prolonging the long-term survival of recipients and kidney allografts. As one of the major approaches of organ preservation, machine perfusion preservation may not only prolong the preservation time and improve the quality of donor kidney, but also play a critical role in the repair and function evaluation of donor kidney. Based on literature review, several hot issues, corresponding treatment strategies and research progress on machine perfusion in the quality maintenance of donor kidney from organ donation after citizen's death were reviewed in this article, aiming to provide reference for selecting the optimal preservation method of donor kidney and enhancing the quality and utilization rate of ECD donor kidney.
