New progress on clinical characteristics and related mechanisms of chronic ocular graft-versus-host disease
10.3969/j.issn.1674-7445.2022.02.006
- VernacularTitle:慢性眼移植物抗宿主病的临床特点及相关机制的新进展
- Author:
Wenxin ZHAO
1
;
Lingyi LIANG
Author Information
1. Zhongshan Ophthalmic Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China
- Publication Type:Research Article
- Keywords:
Chronic ocular graft-versus-host disease (coGVHD);
Allogeneic hematopoietic stem cell transplantation (allo-HSCT);
Meibomian gland dysfunction;
Artificial tear;
B cell activating factor;
Eye-associated lymphoid tissue (EALT);
Interleukin-1 receptor antagonist;
Spleen tyrosine kinase
- From:
Organ Transplantation
2022;13(2):187-
- CountryChina
- Language:Chinese
-
Abstract:
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) could effectively treat multiple hematological diseases. At present, with persistent improvement of transplantation techniques and rapid development of economy, more and more patients with hematological diseases are able to survive for a long time due to allo-HSCT treatment. Chronic ocular graft-versus-host disease (coGVHD) is the most common ocular complication after allo-HSCT, which is primarily manifested with refractory dry eye. In severe cases, it may cause imbalance of ocular surface homeostasis and limbal stem cell insufficiency, further leading to a series of complications that threaten the visual function and eye health, such as corneal perforation and symblepharon, etc. It is highly difficult to cure these symptoms. At present, relevant studies of clinical manifestations, diagnostic criteria, treatment specification and pathogenesis of coGVHD have been gradually deepened within the international community. However, related research and the establishment of clinical specification are still in the primary stage in China. In this article, research progress on clinical characteristics and related mechanisms of coGVHD was reviewed, aiming to deepen the understanding of this disease by ophthalmologists, especially specialists in corneal and ocular surface diseases, and provide novel ideas for subsequent in-depth research.
